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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell / regulatory T cell imbalance in rheumatoid arthritis

Fig. 2

CD4+ T cell differentiation of PBMCs determined by flow cytometry, and levels of IL-17A and soluble RANKL in culture soup under Th17 polarizing condition. PBMCs from RA paitents (N = 5) was cultured under Th17 condition (IL-1β, IL-6, IL-23 added media) with various concentration of IL-18BP (10, 50, 100 ng/mL). (A) CD4+ T cell differentiation was measured by flow cytometry. (B) Levels of IL-17A and soluble RANKL in culture soup was determined by ELISA. *P < 0.05, **P < 0.001, ***P < 0.001

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