Fig. 8

The mechanistic diagram depicting the role of Cbl in HUVEC dysfunction in DM. Cbl blocked the JAK2/STAT4 pathway to downregulate the expression of Runx3 through H3K4me3 modification, thereby alleviating HUVEC dysfunction in DM
The mechanistic diagram depicting the role of Cbl in HUVEC dysfunction in DM. Cbl blocked the JAK2/STAT4 pathway to downregulate the expression of Runx3 through H3K4me3 modification, thereby alleviating HUVEC dysfunction in DM