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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Overexpression of E3 ubiquitin ligase Cbl attenuates endothelial dysfunction in diabetes mellitus by inhibiting the JAK2/STAT4 signaling and Runx3-mediated H3K4me3

Fig. 7

Cbl improves HUVEC dysfunction by inhibiting Runx3 expression and inactivating JAK2/STAT4 pathway. A IHC detecting Runx3-positive percentage in rat aortic tissues and corresponding quantification upon treatment with oe-NC, oe-Cbl + oe-NC, or oe-Cb1 + oe-Runx3 (× 200). B HE staining of rat aortic tissues and corresponding quantification upon treatment with oe-NC, oe-Cbl + oe-NC, or oe-Cb1 + oe-Runx3 (× 200). C Quantification of the aortic relaxation response to ACH and SNP in DM rats or control rats. D Quantification of serum NO content upon treatment with oe-NC, oe-Cbl + oe-NC, or oe-Cbl + oe-Runx3 detected by Griess assay. E TUNEL staining of rat aortic tissues and corresponding quantification upon treatment with oe-NC, oe-Cbl + oe-NC, or oe- + oe-Runx3 (× 200). * p < 0.05 vs. the oe-NC group and # p < 0.05 vs. the oe-Cbl + oe-NC group. Data were measurement data, and presented as mean ± standard deviation. Data among groups were analyzed by one-way ANOVA. n = 6

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