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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Circadian rhythms affect bone reconstruction by regulating bone energy metabolism

Fig. 3

The core molecular circadian clock is present in all mammalian cells and consists of a single unit of positive (CLOCK and BMAL1) and negative (CRY, PER, and REV-ERB alpha). Molecular clocks regulate the expression of hundreds of clock control genes (CCGs), including metabolic media. BMAL1 regulates the activation/cracking of CREBH via AKT-GSK3β signaling. Core circadian oscillations regulate CREBH activity: (1) The core circadian oscillation BMAL1 protein regulates CREBH protein hydrolytic activation; (2) the output circadian rhythm regulator DBP or E4BP4 interacts with the activated CREBH protein to inhibit or synergize with CREBH activity

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