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Table 3 Odds ratios (95%CI) for incident diabetes per SD increase in individual sphingolipid component

From: Identification of circulating sphingosine kinase-related metabolites for prediction of type 2 diabetes

  per SD (nmol/L) Unadjusted Model 1 Model 2 Model 3
OR (95%CI) P value OR (95%CI) P value OR (95%CI) P value OR (95%CI) P value
Sph 7.22 1.283 (0.953–1.729) 0.101 1.328 (0.967–1.823) 0.080 1.343 (0.974–1.852) 0.072 1.244 (0.878–1.764) 0.220
S1P 159.7 1.190 (0.896–1.579) 0.229 1.229 (0.911–1.657) 0.177 1.247 (0.918–1.696) 0.158 1.113 (0.801–1.545) 0.524
S1P/Sph 32.6 0.915 (0.692–1.210) 0.534 0.944 (0.705–1.265) 0.701 0.946 (0.705–1.269) 0.711 0.999 (0.732–1.364) 0.996
dhSph 1.18 0.808 (0.608–1.075) 0.144 0.804 (0.593–1.092) 0.163 0.818 (0.600–1.115) 0.204 0.711 (0.507–0.997) 0.048
dhS1P 48.0 1.535 (1.124–2.096) 0.007 1.586 (1.137–2.212) 0.007 1.632 (1.146–2.326) 0.007 1.498 (1.050–2.138) 0.026
dhS1P/dhSph 24.1 1.541 (1.095–2.168) 0.013 1.536 (1.084–2.176) 0.016 1.546 (1.065–2.244) 0.022 1.695 (1.137–2.526) 0.009
  1. Data were odds ratio (95% confidence interval)
  2. Model 1 included terms for age, sex and BMI changes
  3. Model 2 included terms for age, sex, BMI changes, family history of diabetes, FPG and OGTT 2 h-blood glucose
  4. Model 3 included terms for age, sex, BMI changes, family history of diabetes, FPG, OGTT 2 h-blood glucose, total cholesterol, triglycerides, systolic blood pressure and uric acid