Identification of circulating sphingosine kinase-related metabolites for prediction of type 2 diabetes

Table 3 Odds ratios (95%CI) for incident diabetes per SD increase in individual sphingolipid component

	per SD (nmol/L)	Unadjusted		Model 1		Model 2		Model 3
	per SD (nmol/L)	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
Sph	7.22	1.283 (0.953–1.729)	0.101	1.328 (0.967–1.823)	0.080	1.343 (0.974–1.852)	0.072	1.244 (0.878–1.764)	0.220
S1P	159.7	1.190 (0.896–1.579)	0.229	1.229 (0.911–1.657)	0.177	1.247 (0.918–1.696)	0.158	1.113 (0.801–1.545)	0.524
S1P/Sph	32.6	0.915 (0.692–1.210)	0.534	0.944 (0.705–1.265)	0.701	0.946 (0.705–1.269)	0.711	0.999 (0.732–1.364)	0.996
dhSph	1.18	0.808 (0.608–1.075)	0.144	0.804 (0.593–1.092)	0.163	0.818 (0.600–1.115)	0.204	0.711 (0.507–0.997)	0.048
dhS1P	48.0	1.535 (1.124–2.096)	0.007	1.586 (1.137–2.212)	0.007	1.632 (1.146–2.326)	0.007	1.498 (1.050–2.138)	0.026
dhS1P/dhSph	24.1	1.541 (1.095–2.168)	0.013	1.536 (1.084–2.176)	0.016	1.546 (1.065–2.244)	0.022	1.695 (1.137–2.526)	0.009

Data were odds ratio (95% confidence interval)
Model 1 included terms for age, sex and BMI changes
Model 2 included terms for age, sex, BMI changes, family history of diabetes, FPG and OGTT 2 h-blood glucose
Model 3 included terms for age, sex, BMI changes, family history of diabetes, FPG, OGTT 2 h-blood glucose, total cholesterol, triglycerides, systolic blood pressure and uric acid

ISSN: 1479-5876