Characteristic | Control (n = 100) | Incident T2DM (n = 100) | P value |
---|---|---|---|
Age, years | 66.8 (60.3–74.0) | 66.3 (60.3–72.2) | 0.999 |
Body mass index, kg/m2 | 24.9 ± 3.1 | 25.7 ± 3.4 | 0.080 |
Waist circumference, cm | 83.1 ± 9.2 | 85.5 ± 9.8 | 0.083 |
Total Cholesterol (mmol/L) | 5.06 (4.41–5.64) | 5.13 (4.37–5.80) | 0.500 |
LDL (mmol/L) | 2.94 ± 0.80 | 2.87 ± 0.89 | 0.523 |
HDL (mmol/L) | 1.42 (1.12–1.69) | 1.33 (1.16–1.62) | 0.602 |
Triglycerides (mmol/L) | 1.37 (1.06–1.78) | 1.72 (1.27–2.30) | 0.026 |
Fasting plasm glucose (mmol/L) | 5.30 (5.10–5.60) | 6.10 (5.45–7.25) |  < 0.001 |
OGTT 2 h-plasm glucose (mmol/L) | 6.10 (5.45–6.90) | 12.1 (11.3–13.8) |  < 0.001 |
Insulin (μU/mL) | 6.90 (5.00–9.80) | 10.8 (6.50–15.7) |  < 0.001 |
HOMA-IR | 1.62 (1.11–2.33) | 2.81 (1.69–4.81) |  < 0.001 |
Uric acid (μmol/L) | 309.0 (256.0–379.5) | 321.0 (265.5–377.5) | 0.774 |
Systolic blood pressure (mmHg) | 138.0 ± 20.2 | 142.0 ± 18.4 | 0.149 |
Diastolic blood pressure (mmHg) | 77.1 ± 11.5 | 78.5 ± 8.6 | 0.335 |
Sphingolipids (nmol/L) | Â | Â | Â |
 Sph | 12.6 (7.58–19.1) | 14.3 (6.8–20.7) | 0.110 |
 S1P | 740.5 (575.7–987.1) | 781.1 (550.3–1072) | 0.225 |
 S1P/Sph | 60.3 (43.8–94.1) | 59.9 (39.6–93.8) | 0.497 |
 dhSph | 2.88 (2.09–3.87) | 3.03 (2.15–3.74) | 0.570 |
 dhS1P | 132.2 (107.7–174.2) | 166.6 (103.6–203.3) | 0.021 |
 dhS1P/dhSph | 45.0 (35.6–63.9) | 54.8 (44.0–66.3) | 0.024 |