Fig. 2

Circulating dhS1P and dhS1P/dhSph ratio are elevated before the occurance of T2DM. Levels of circulating SphK-related sphingolipids, including Sph, S1P, dhSph and dhS1P were measured in the control (n = 100) and incident diabetic groups (n = 100) at the time points of baseline and follow-up, respectively. Data are expressed as median with the interquartile range. **P < 0.01, incident diabetes compared with the controls