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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: A direct negative feedback loop of miR-4721/FOXA1/Nanog promotes nasopharyngeal cell stem cell enrichment and metastasis

Fig. 6

Relationship between miR-4721, FOXA1 and Nanog. A Expression levels of miR-4721, FOXA1 and Nanog in NPC specimens, as detected by in situ hybridization and immunohistochemistry. a: strong expression of miR-4721; b: low staining of FOXA1; c: strong expression of Nanog; d: low staining of miR-4721; e: strong expression of miR-FOXA1; f: low staining of Nanog; The scale bars are 200 and 50 μm respectively. B Two-tailed Spearman’s correlation analysis was performed to calculate the correlations between FOXA1 and miR-4721 expression levels. P = 0.0039; r = − 0.2498. C Two-tailed Spearman’s correlation analysis was performed to calculate the correlations between Nanog and FOXA1 expression levels. P = 0.0151; r = − 0.2111. D Two-tailed Spearman’s correlation analysis was performed to calculate the correlations between Nanog and miR-4721 expression levels. P = 0.0008; r = 0.2298. E According to the FOXA1 protein expression, Kaplan–Meier survival analysis was performed on the overall survival of 132 NPC patients. F Patients with low miR-4721 expression and high FOXA1 expression survive longer in NPC specimens. **P < 0.01

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