Fig. 1

Bufalin suppresses angiogenesis induced by cells in the tumour microenvironment cells. a Molecular structure of BU. b Cell viability of HUVECs after treated with BU for 24 h. c Cell proliferation of HUVECs after treated with different TME-CMs for 24 h. The effect of bufalin (BU) on the tube formation (d), migration (e) and adhesion (f) of HUVECs in response to different TME-CMs. *P < 0.05, **P < 0.01, ***P < 0.001. Data are shown as mean s.e.m. BU, bufalin