Table 3 Univariate and multivariate Cox analyses of disease-free survival prediction, based on IRF scores calculated by cases from TCGA
Variable | Univariate Cox analysis | Multivariate Cox analysis | ||
|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Age (≥ 60 vs. < 60) | 1.00 (0.60–1.69) | 0.975 | 1.02 (0.59–1.78) | 0.934 |
Gender (male vs. female) | 1.15 (0.72–1.84) | 0.567 | 0.75 (0.46–1.24) | 0.263 |
T stage (T3 and T4 vs. T1 and T2) | 8.40 (2.06–34.31) | 0.003 | 3.41 (0.82–14.17) | 0.091 |
N stage (N1 and N2 vs. N0) | 4.77 (2.77–8.24) |  < 0.001 | 0.74 (0.28–1.96) | 0.547 |
M stage (M1 and MX vs. M0) | 5.57 (3.45–8.99) |  < 0.001 | 2.99 (1.72–5.18) | 0.001 |
Stage (III + IV vs. I + II) | 6.52 (3.57–11.91) |  < 0.001 | 3.32 (1.04–10.61) | 0.043 |
IRF score (high vs. low) | 1585.65 (372.03–6758.19) |  < 0.001 | 1855.25 (335.16–10,269.55) |  < 0.001 |