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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Interferon regulatory factor family influences tumor immunity and prognosis of patients with colorectal cancer

Fig. 4

Differentially expressed gene (DEG) and functional-enrichment analysis between high- and low-IRF groups. A, B Volcano and heat maps showed 126 DEGs between high- and low-IRF groups. C The Gene Ontology analysis suggested that DEGs were closely correlated to the terms such as gas transport, antimicrobial humoral response, humoral immune response, and sensory organ morphogenesis. D The five most significant pathways, including Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, Nitrogen metabolism, Salivary secretion, and Staphylococcus aureus infection, and their corresponding gene information were shown after Kyoto Encyclopedia of Genes and Genomes enrichment analysis. E Volcanic maps exhibited Gene-Set Enrichment Analysis results for upregulated and downregulated pathways. The X axis represented the relative enrichment score corresponding to the pathway after the Gene Set Enrichment Analysis, and the Y axis represented the names of the most significant pathways obtained by enrichment analysis. F Patients in the high-IRF group showed correlations with the terms as ribosome and cardiac muscle contraction pathways, whereas the terms hematopoietic cell lineage, intestinal immune network for IgA production, while chemokine signaling pathway (among other pathways) were significantly underrepresented for patients in the high-IRF group

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