Fig. 2

TEXscore holds promise in discriminating of tumor and normal tissues in the TCGA-Pan-Cancer cohort. A TEXscore increased along with the ascending malignancy degrees of lung tissues in GSE33479. Spearman rank correlation rho = 0.3968921, P = 6.011e−06. B TEXscore was elevated in most cancer types in the tumor tissues compared with normal tissues in the TCGA-Pan-Cancer cohort. C–F The capacity to identify tumor sources or normal tissues sources of TEXscore in the (C) TCGA-LUAD cohort, (D) TCGA-LUSC cohort, (E) TCGA-OV cohort, and (F) TCGA-PRAD cohort. (TCGA-LUAD: AUC = 0.891; TCGA-LUSC: AUC = 0.85; TCGA-OV: AUC = 0.798; TCGA-PRAD: AUC = 0.731.) P-values are shown with ****, ***, **, ns representing P < 0.0001, P < 0.001, P < 0.01, no significant, respectively