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Table 4 Four modules from the PPI network with the criteria of MCODE score > 4 and number of nodes > 4

From: GSK2126458 has the potential to inhibit the proliferation of pancreatic cancer uncovered by bioinformatics analysis and pharmacological experiments

Cluster

Score

Nodes

Edges

Node IDs

1

19.128

40

373

IFITM1, IFI35, CXCL9, CXCL10, GBP2, FPR1, ANXA1, CCL19, CXCL13, NMU, C5AR1, GNAI1, GBP1, AGT, HLA-B, PSMB8, C3, SAMD9, SUCNR1, MX1, CXCL3, ISG15, IFITM3, IFIT1, OAS1, C3AR1, RSAD2, IFI6, IFI44, IFI27, CCL20, DDX60, MX2, CXCR4, UBE2L6, C5, XAF1, RNASEL, IFI44L, RTP4

2

12.062

33

193

ALB, EGF, HTR2B, VEGFC, CCKBR, PLOD2, HRH1, SERPINE1, EDNRA, PLAU, F8, SERPINH1, COL16A1, TIMP1, PLCB1, P4HB, PROS1, COL11A1, LGALS3BP, ISLR, COL4A1, COL4A2, COL10A1, COL8A1, FGG, TNC, FN1, COL5A1, CHRM3, SPARC, COL3A1, F2R, COL1A2

3

6.556

19

59

COMP, EREG, DLGAP5, TUBA1C, TOP2A, CTSE, LUM, TUBA4A, GMNN, FBN1, NDC80, THBS2, CKS2, CCNB1, ANLN, RND3, CEP55, CENPK, FAM83D

4

6.545

23

72

CD14, ITGB2, SDC1, IGFBP3, CD163, F3, CRP, MMP7, CD69, MMP1, C1orf162, PLAT, NCF2, CCL18, VSIG4, MMP9, CTSB, FCGR3B, FCER1G, C1QA, ALOX5AP, C1QB, IL18

  1. Score = Density*#Nodes