Fig. 1

Different strategies could be used to inhibit Tfh cells during SSc. APC: antigen presenting cell, BCL-6: B cell lymphoma 6, BLIMP-1: B lymphocyte-induced maturation protein 1, CAR: chimeric antigen receptor, CD: cluster differentiation, CTLA-4: cytotoxic T-lymphocyte-associated protein 4, CXCR5: C-X-C motif chemokine receptor 5, Il: interleukin, ICOS: inducible T-cell costimulator, JAK: janus kinase, NK: natural killer, PD-1: programme death, PD-L1: programmed death ligand, TFH: T follicular helper, Prdm-1: PR domain zinc finger protein 1, STAT: signal transducer and activator of transcription 1, TGF-β: transforming growth factor-β