Table 2 Comparison of laboratory index
From: Applying low coverage whole genome sequencing to detect malignant ovarian mass
Group | Counts | Mean±SD | Median (0.25-0.75) | Median (0.025–0.975) | Min | Max | CV | P |
|---|---|---|---|---|---|---|---|---|
AGE (years) | ||||||||
 Benign mass | 19 | 34.474±10.808 | 30 (27–41.5) | 30 (18.05–52.4) | 14 | 56 | 31.35% | 0.001** |
 Malignancy mass | 44 | 48.25±13.404 | 51.5 (39–56.25) | 51.5 (21.075–70.85) | 18 | 73 | 27.78% | |
 Total | 63 | 44.095±14.112 | 46 (35–55) | 46 (19.65–69.9) | 14 | 73 | 32.00% |  |
CA125 (U/ml) | ||||||||
 Benign mass | 19 | 83.387±112.353 | 24.89 (13.765–78.24) | 24.89 (7.425–336.055) | 6.98 | 390.1 | 134.74% | 0.001** |
 Malignancy mass | 44 | 560.282±854.994 | 214.7 (65.523–428.975) | 214.7 (8.025–2986.7) | 6.98 | 3190.6 | 152.60% | |
 Total | 63 | 416.457±747.887 | 86.62 (25.445–318.2) | 86.62 (7.524–2756.8) | 6.98 | 3190.6 | 179.58% |  |
HE4 (U/ml) | ||||||||
 Benign mass | 19 | 63.595±51.849 | 45.49 (40.175–53.49) | 45.49 (34.13–199.065) | 31.7 | 251.4 | 81.53% | 0.000** |
 Malignancy mass | 44 | 286.382±534.32 | 128.55 (60.925–220.55) | 128.55 (45.6–1458.577) | 45.49 | 3235.9 | 186.58% | |
 Total | 63 | 219.192±457.614 | 67.8 (46.71–167.65) | 67.8 (38.206–1196.235) | 31.7 | 3235.9 | 208.77% |  |
ROMA | ||||||||
 Benign mass | 19 | 0.189±0.278 | 0.06 (0.045–0.13) | 0.06 (0.034–0.905) | 0.03 | 0.99 | 147.09% | 0.000** |
 Malignancy mass | 44 | 0.683±0.387 | 0.96 (0.277–1) | 0.96 (0.06–1) | 0.06 | 1 | 56.66% | |
 Total | 63 | 0.534±0.422 | 0.52 (0.075–1) | 0.52 (0.04–1) | 0.03 | 1 | 79.03% |  |
CNV | ||||||||
 Benign mass | 19 | 2.579±1.805 | 2 (1.5–3.5) | 2 (0–6.1) | 0 | 7 | 69.99% | 0.000** |
 Malignancy mass | 44 | 14.432±27.812 | 5 (3–11.5) | 5 (0–69.575) | 0 | 168 | 192.71% | |
 Total | 63 | 10.857±23.822 | 4 (2–8.5) | 4 (0–60.55) | 0 | 168 | 219.42% |  |
Zmax | ||||||||
 Benign mass | 19 | 4.937±2.6 | 5.06 (3.445–6.36) | 5.06 (0–9.623) | 0 | 11.22 | 52.66% | 0.021* |
 Malignancy mass | 44 | 10.421±11.091 | 6.05 (4.672–10.973) | 6.05 (0–47.258) | 0 | 52.77 | 106.43% | |
 Total | 63 | 8.767±9.681 | 5.66 (4.455–9.745) | 5.66 (0–39.833) | 0 | 52.77 | 110.43% |  |
Zmean | ||||||||
 Benign mass | 19 | 3.676±1.499 | 3.83 (3.305–4.305) | 3.83 (0–5.429) | 0 | 5.51 | 40.78% | 0.005** |
 Malignancy mass | 44 | 5.059±2.536 | 4.77 (4.245–5.66) | 4.77 (0–12.228) | 0 | 12.53 | 50.13% | |
 Total | 63 | 4.642±2.35 | 4.46 (3.69–5.265) | 4.46 (0–11.71) | 0 | 12.53 | 50.62% |  |
RM | ||||||||
 Benign mass | 19 | 0.879±2.304 | 0.32 (− 0.04-0.84) | 0.32 (− 0.683–6.699) | − 0.71 | 9.79 | 262.12% | 0.000** |
 Malignancy mass | 44 | 63.872±216.976 | 4.73 (1.532–16.795) | 4.73 (− 0.139–608.251) | − 0.15 | 1289.65 | 339.70% | |
Total | 63 | 44.874±183.035 | 2.39 (0.185–10.185) | 2.39 (− 0.502–468.421) | − 0.71 | 1289.65 | 407.89% |  |
|  | Benign mass (N = 19) | Malignancy mass (N = 44) | Total (N = 63) | X² | P |
|---|---|---|---|---|---|
Marriage | |||||
 Yes | 16 (84.2%) | 40 (90.9%) | 56 (88.9%) | 0.115 | 0.734 |
 No | 3 (15.8%) | 4 (9.1%) | 7 (11.1%) | ||
Childbirth | |||||
 Yes | 14 (73.7%) | 40 (90.9%) | 54 (85.7%) | 1.962 | 0.161 |
 No | 5 (26.3%) | 4 (9.1%) | 9 (14.3%) | ||
Menopausal status | |||||
 PreMenopausal | 18 (94.7%) | 22 (50.0%) | 40 (63.5%) | 11.457 | 0.001** |
 PostMenopausal | 1 (5.3%) | 22 (50.0%) | 23 (36.5%) | ||