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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Transcriptomic analysis of tumor tissues and organoids reveals the crucial genes regulating the proliferation of lung adenocarcinoma

Fig. 3

Screening of lung adenocarcinoma-related genes based on organoid and tissue analysis. a Intersection of the genes enriched in the pathways in Fig. 1B and Fig. 2C was taken, and 88 genes were obtained. Gene cluster A: genes upregulated in LUAD tissue and organoid; Gene cluster B: genes upregulated in LUAD and LUSC tissue but no difference between LUAD and LUSC organoid. b, c Heatmaps showed 40 genes upregulated in LUSC (n = 49) tissues compared with the matched normal tissues (b, LogFC > 1, P < 0.001) and 22 genes upregulated in LUAD (n = 58) tissues compared with the matched normal tissues (c, LogFC > 1, P < 0.001). d Venn diagram showed the overlapping 21 genes upregulated in LUAD (n = 58) and LUSC (n = 49) tissues compared with the matched normal tissues. e Pathways analysis by Metascape revealed the enriched pathways of the overlapping 21 genes

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Journal of Translational Medicine

ISSN: 1479-5876

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