Fig. 1

Transcriptomic analysis based on organoids and tissues revealed the mechanisms of LUAD and LUSC respectively. a Venn diagram showed the intersection of pathways enriched in LUAD tissues compared with normal tissues (58 paired LUAD tissues and normal tissues) and pathways enriched in LUAD organoids compared with LUAD tissues (6 paired LUAD organoids and tissues). b Bubble diagram showed 18 pathways enriched in LUAD tissues compared with normal tissues, which were also enriched in LUAD organoids compared with LUAD tissues. c Venn diagram showed the intersection of pathways enriched in LUSC tissues compared with normal tissues (49 paired LUSC tissues and normal tissues) and pathways enriched in LUSC organoids compared with LUSC tissues (2 paired LUSC organoids and tissues). d Bubble diagram showed eight pathways enriched in LUSC tissues compared with normal tissues, which were also enriched in LUSC organoids compared with LUSC tissues. up upregulated genes, down downregulated genes; no no difference