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Table 2 Effect of Metformin administration on lung histopathology in the early stage

From: Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling

Groups Lesion severity grade Average severity grade Lesion distribution grade Average distribution grade
0 1 2 3 4 5 0 1 2 3 4 5
Saline 6       6      
Silica     2 3 1 3.83 ± 0.307    1 3 1 1 3.33 ± 0.42
Silica + saline     1 4 1 4.00 ± 0.25    3 2 1   2.67 ± 0.33
Silica + metformin 1 2 3     1.33 ± 0.33a 2 3 1     0.83 ± 0.32a
  1. Values represent the means ± SD of 6 for each group
  2. ap < 0.05 vs. Silica + Saline group (independent-sample t-test)