Table 2 Effect of Metformin administration on lung histopathology in the early stage
From: Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling
| Groups | Lesion severity grade | Average severity grade | Lesion distribution grade | Average distribution grade | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | 5 | 0 | 1 | 2 | 3 | 4 | 5 | |||
| Saline | 6 | – | 6 | – | ||||||||||
| Silica | 2 | 3 | 1 | 3.83 ± 0.307 | 1 | 3 | 1 | 1 | 3.33 ± 0.42 | |||||
| Silica + saline | 1 | 4 | 1 | 4.00 ± 0.25 | 3 | 2 | 1 | 2.67 ± 0.33 | ||||||
| Silica + metformin | 1 | 2 | 3 | 1.33 ± 0.33a | 2 | 3 | 1 | 0.83 ± 0.32a | ||||||