Table 2 Effect of Metformin administration on lung histopathology in the early stage
From: Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling
Groups | Lesion severity grade | Average severity grade | Lesion distribution grade | Average distribution grade | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
0 | 1 | 2 | 3 | 4 | 5 | 0 | 1 | 2 | 3 | 4 | 5 | |||
Saline | 6 |  |  |  |  |  | – | 6 |  |  |  |  |  | – |
Silica |  |  |  | 2 | 3 | 1 | 3.83 ± 0.307 |  |  | 1 | 3 | 1 | 1 | 3.33 ± 0.42 |
Silica + saline |  |  |  | 1 | 4 | 1 | 4.00 ± 0.25 |  |  | 3 | 2 | 1 |  | 2.67 ± 0.33 |
Silica + metformin | 1 | 2 | 3 |  |  |  | 1.33 ± 0.33a | 2 | 3 | 1 |  |  |  | 0.83 ± 0.32a |