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Table 1 Effect of Metformin administration on lung histopathology in the late stage

From: Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling

Groups Lesion severity grade Average severity grade Lesion distribution grade Average distribution grade
0 1 2 3 4 5 0 1 2 3 4 5
Saline 6       6      
Silica     1 2 3 4.33 ± 0.33    1 1 3 1 3.67 ± 0.42
Silica + 100 mg/kg metformin   2    4   3.67 ± 0.84   2 4     1.67 ± 0.21a
Silica + 300 mg/kg metformin 1 3 1    1 1.67 ± 0.71a 1 4 1     1.00 ± 0.26a
  1. Values represent the means ± SD of 6 for each group
  2. ap < 0.05 vs. silica group (independent-sample t-test)