Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling

Table 1 Effect of Metformin administration on lung histopathology in the late stage

Groups	Lesion severity grade						Average severity grade	Lesion distribution grade						Average distribution grade
Groups	0	1	2	3	4	5	Average severity grade	0	1	2	3	4	5	Average distribution grade
Saline	6						–	6						–
Silica				1	2	3	4.33 ± 0.33			1	1	3	1	3.67 ± 0.42
Silica + 100 mg/kg metformin		2			4		3.67 ± 0.84		2	4				1.67 ± 0.21^a
Silica + 300 mg/kg metformin	1	3	1			1	1.67 ± 0.71^a	1	4	1				1.00 ± 0.26^a

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