Fig. 7
From: Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling
Metformin inhibits the TGF-β1-stimulated FMT process in pulmonary fibroblasts. A The protein levels of Fibronectin, Collagen I and α-SMA in MRC-5 cells are treated by different doses of TGF-β1. B Western blotting showing Fibronectin, Collagen I and α-SMA protein levels with TGF-β1 and metformin co-treatment in MRC-5 cells. C qRT-PCR detection of α-SMA mRNA expression in MRC-5 cells after cultured with TGF-β1 and different doses of metformin, with **p < 0.01 vs. control and #p < 0.05 vs. the TGF-β1 group. D Wound-healing assay and quantified wound gap of cell scratches detected the migration of MRC-5 cells for the indicated groups, with *p < 0.05 vs. the TGF-β1 group