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Table 3 Spearman correlation of lipids identified by PCA with ME/CFS symptoms

From: Sex-specific plasma lipid profiles of ME/CFS patients and their association with pain, fatigue, and cognitive symptoms

PC1 PC2 PC3
Lipids Headache Physical pain Cognitive difficulties Fatigue Lipids Headache Physical pain Cognitive difficulties Fatigue Lipids Headache Physical pain Cognitive difficulties Fatigue
PC 32:2 − 0.039 0.178 − 0.073 0.217 PC 40:6 − 0.127 0.090 − 0.244 − 0.464** ePC 34:3 − 0.409* − 0.295 0.09 − 0.097
PC 32:3 − 0.065 0.185 − 0.071 0.085 PC 38:7 − 0.315 − 0.082 − 0.271 − 0.471** PC 36:2 − 0.338 − 0.124 0.018 0.021
PC 34:4 − 0.079 0.172 − 0.166 0.024 PC 40:7 − 0.271 − 0.152 − 0.271 − 0.471** ePC 38:4 − 0.254 − 0.108 0.133 0.008
PC 34:5 − 0.105 0.120 − 0.180 − 0.188 PC 36:5 − 0.184 0.012 − 0.254 − 0.393* PC 34:2 − 0.244 − 0.021 0.118 0.206
PC 34:3 − 0.196 0.140 − 0.147 0.036 PC 36:6 − 0.143 0.117 − 0.273 − 0.336 PC 40:3 − 0.373 − 0.250 − 0.068 − 0.012
SM(d18:1/14:1) − 0.260 − 0.049 − 0.301 − 0.169 PC 38:5 − 0.179 − 0.04 − 0.316 − 0.398* PC 36:3 − 0.226 0.010 0.052 0.158
PC 36:6 − 0.143 0.117 − 0.273 − 0.336 PC 42:6 − 0.122 − 0.161 − 0.237 − 0.252 SM(d18:1/16:0) − 0.356 − 0.118 − 0.098 − 0.264
PC 36:3 − 0.226 0.010 0.052 0.158 SM(d18:1/16:0) − 0.356 − 0.118 − 0.098 − 0.264 PC 38:2 − 0.201 − 0.069 − 0.139 − 0.007
PC 38:2 − 0.201 − 0.069 − 0.139 − 0.007 PC 34:5 − 0.105 0.120 − 0.180 − 0.188 PC 38:1 − 0.192 − 0.163 − 0.044 − 0.094
PC 34:2 − 0.244 − 0.021 0.118 0.206 SM(d18:1/16:1) − 0.311 − 0.115 − 0.209 − 0.265 SM(d18:1/16:1) − 0.311 − 0.115 − 0.209 − 0.265
PI 36:3 − 0.179 − 0.032 − 0.122 0.039 PC 38:1 − 0.192 − 0.163 − 0.044 − 0.094 PC 38:4 − 0.206 0.073 − 0.232 − 0.240
PI 34:1 − 0.102 0.085 0.017 0.269 SM(d18:1/18:1) − 0.216 0.068 − 0.189 − 0.292 PC 34:3 − 0.196 0.140 − 0.147 0.036
PI 38:3 − 0.143 0.200 − 0.158 0.125 SM(d18:1/14:1 − 0.260 − 0.049 − 0.301 − 0.169 PC 38:3 0.008 0.252 − 0.030 0.158
SM(d18:1/16:1) − 0.311 − 0.115 − 0.209 − 0.265 PC 42:5 − 0.093 − 0.028 − 0.210 − 0.069      
PC 36:2 − 0.338 − 0.124 0.018 0.021 PC 40:3 − 0.373 − 0.250 − 0.068 − 0.012      
Cer 40:3 − 0.048 0.144 − 0.207 0.052 LPC 18:1 − 0.352 − 0.273 − 0.081 − 0.104      
PC 38:3 0.008 0.252 − 0.030 0.158           
  1. The coefficient of correlation of each individual lipid from the 3 principal components (PC1, PC2 and PC3) with the severity of headache, physical pain, cognitive difficulties or fatigue is reported in the table. Asterisks show significant correlations using adjusted p-values after B–H correction (*p < 0.05; **p < 0.01)