Fig. 3

GO enrichment and KEGG pathway enrichment analysis for the targeted genes in the ceRNA network. A KEGG enrichment analysis for the differentially expressed targeted genes in the ceRNA network. The horizontal axis indicates the enrichment factor, which represents the enrichment level of differentially expressed genes. The vertical axis displays the regulatory pathways involved in SLE pathogenesis. B GO analysis of the differentially expressed targeted genes in the ceRNA network. The horizontal axis indicates the names of hierarchical clusters in cellular component (CC), biological process (BP) and molecular function (MF). The vertical axis displays the number of targeted genes in a particular hierarchical cluster. The GO terms were sorted by the thresholds of mRNA fold change and enrichment level (|log2 fold change |≥ 2 and P-value < 0.05)