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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Urinary small extracellular vesicles derived CCL21 mRNA as biomarker linked with pathogenesis for diabetic nephropathy

Fig. 3

Urinary small EVs derived CCL21 mRNA in different stages of DN divided by histological damage. A The expression of CCL21 mRNA in urinary small EVs of DN patients with normal (0, n  =  7), mild (<  25%, n  =  11) or severe (>  25%, n  =  10) tubulointerstitial inflammation. Urinary small EVs derived CCL21 mRNA expression increased progressively with the deterioration of tubulointerstitial inflammation. (****p  <  0.0001, compared with normal group; ####p  <  0.0001, compared with mild group). B Urinary small EVs derived CCL21 expression in DN patients based on glomerular classification (*p  <  0.05 compared with patients with class II)

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