Fig. 3
Urinary small EVs derived CCL21 mRNA in different stages of DN divided by histological damage. A The expression of CCL21 mRNA in urinary small EVs of DN patients with normal (0, n = 7), mild (< 25%, n = 11) or severe (> 25%, n = 10) tubulointerstitial inflammation. Urinary small EVs derived CCL21 mRNA expression increased progressively with the deterioration of tubulointerstitial inflammation. (****p < 0.0001, compared with normal group; ####p < 0.0001, compared with mild group). B Urinary small EVs derived CCL21 expression in DN patients based on glomerular classification (*p < 0.05 compared with patients with class II)