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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Dexmedetomidine inhibits mitochondria damage and apoptosis of enteric glial cells in experimental intestinal ischemia/reperfusion injury via SIRT3-dependent PINK1/HDAC3/p53 pathway

Fig. 1

Dex reduces oxidative stress and consequently alleviates intestinal I/R injury in rats. A Intestinal histopathological changes in rats. B Intestinal damage assessed by Chiu’s score. C Intestinal W/D ratio. D Level of MDA in intestinal tissues of rats. E SOD activity in intestinal tissues of rats. F Serum expression of TNF-α in rats. G Serum expression of IL-6 in rats. H The positive expression of GFAP and S-100β in the intestinal tissue of rats evaluated by IHC. I Western blot analysis for determination of protein expression of S-100β and GFAP in intestinal tissues of rats. J The apoptosis of EGCs in intestinal tissues of rats examined by TUNEL. *p < 0.05 vs. sham-operated rats; #p < 0.05 vs. rats with I/R injury; &p < 0.05 vs. rats with Dex1 (2.5 μg/(kg/h) Dex) treatment. Measurement data were expressed as mean ± standard deviation. Comparison among multiple groups was conducted by one-way ANOVA with Tukey’s post hoc test. N = 10

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