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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Knockdown of long noncoding RNA GAS5 reduces vascular smooth muscle cell apoptosis by inactivating EZH2-mediated RIG-I signaling pathway in abdominal aortic aneurysm

Fig. 1

AAA mice present with low EZH2 expression and its upregulation attenuates AAA development. A The cross sections of abdominal aorta in AAA and control mice detected by HE staining. B The outer diameter of abdominal aorta of AAA and control mice. C The expression of EZH2 in aortic tissues of AAA and control mice determined by RT-qPCR. D Western blot analysis of EZH2 protein in aortic tissues of AAA and control mice. E Immunohistochemistry of EZH2 protein in aortic tissues of AAA and control mice (200 ×). F The expression of EZH2 in aortic tissues of control mice and AAA mice upon treatment with oe-NC and oe-EZH2 determined by RT-qPCR. G Western blot analysis of EZH2 protein in aortic tissues of control mice and AAA mice upon treatment with oe-NC and oe-EZH2. β-actin served as internal reference of EZH2. H Quantification of maximum abdominal aortic diameter of control mice and AAA mice upon treatment with oe-NC and oe-EZH2 *p < 0.05 indicates significant difference. Data in AH were compared using unpaired t-test. n = 6 for mice following each treatment

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