Fig. 5

HDGF-mediated STAT3 phosphorylation in combination with transketolase. A Effects of STAT3–Tyr705 and STAT3–Ser727 phosphorylation levels in TKT knockdown breast cancer cells. B Quantification of protein in (A). C Effects of TKT rescue HDGF knockdown on STAT3–Tyr705 and STAT3–Ser727 phosphorylation levels. D Quantification of protein in (C). E, F TKT overexpression rescue HDGF knockdown-inhibited cell proliferation (E) and surviving fractions (F) after irradiation. G HDGF knockdown inhibits TKT association with STAT3. H TKT knockdown inhibits HDGF association with STAT3. As shown in B, D, E, and F Error bars ± S.D. *P < 0.05. ***P < 0.001. Data are representative of three independent experiments