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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Heparin-binding growth factor (HDGF) drives radioresistance in breast cancer by activating the STAT3 signaling pathway

Fig. 1

HDGF overexpression in breast cancer and its negative correlation with the survival prognosis of patients. A HDGF copy number analysis in TCGA breast cancer dataset. Data were downloaded from http://xena.ucsc.edu/public-hubs. B HDGF expression is higher in breast cancer tissues than that in adjacent normal tissues. Expression data of HDGF were downloaded from the REMBRANDT dataset. Data are presented as mean ± SEM.***P < 0.001, by two-tailed t-test. C, D HDGF expression is negatively correlated with patients' disease-free survival (C) and distance metastasis-free survival (D). Data were retrieved from Kaplan–Meier Plotter (http:// kmplot.com/ analysis/index). E HDGF protein is upregulated in breast cancer (MCF7, MDA-MB-231, BT549, and MDA-MB-453) compared with that in the normal MCF10A cells. F Quantification of HDGF protein in E. G, H HDGF is upregulated in breast cancer I.R. cell lines at the mRNA (G) and protein level (H). I Quantification of HDGF protein in (H). As shown in B, F, G, and I, Error bars ± S.D. *P < 0.05. ***P < 0.001. Data are representative of three independent experiments

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