|
Factors
|
Univariate analysis
|
Multivariate analysisa
|
Multivariate analysisb
|
|---|
|
OR (95% CI)
|
P
|
OR (95% CI)
|
P
|
OR (95% CI)
|
P
|
|---|
|
pCR-score
|
3.516 (2.003–6.173)
|
< 0.001
|
–
|
–
|
4.045 (1.822–8.980)
|
0.001
|
|
Subtypes
|
–
|
< 0.001
|
–
|
0.003
|
–
|
0.084
|
|
HR +/HER2-
|
1
|
1
|
1
|
1
|
1
|
1
|
|
HR +/HER2 +
|
8.939 (1.861–42.944)
|
0.006
|
8.049 (1.484–43.664)
|
0.016
|
2.899 (0.395–21.282)
|
0.295
|
|
HR-/HER2 −
|
5.900 (1.041–33.477)
|
0.045
|
4.798 (0.733–31.387)
|
0.102
|
2.327 (0.262–20.671)
|
0.449
|
|
HR-/HER2 +
|
32.778 (7.031–152.815)
|
< 0.001
|
21.497 (4.089–113.00)
|
< 0.001
|
12.923 (1.783–93.638)
|
0.011
|
|
sTILs density
|
–
|
0.002
|
–
|
0.041
|
–
|
0.060
|
|
Low
|
1
|
1
|
1
|
1
|
1
|
1
|
|
Moderate
|
7.673 (2.302–25.581)
|
0.001
|
5.374 (1.311–22.021)
|
0.019
|
8.256 (1.404–48.546)
|
0.020
|
|
High
|
14.250 (2.143–94.741)
|
0.006
|
9.206 (0.939–90.247)
|
0.057
|
7.379 (0.511–106.471)
|
0.142
|
|
T stage
|
0.754 (0.290–1.962)
|
0.563
|
1.515 (0.428–5.356)
|
0.519
|
2.219 (0.487–10.119)
|
0.303
|
|
Ki67
|
4.571 (0.571–36.610)
|
0.152
|
1.166 (0.116–11.737)
|
0.897
|
1.859 (0.142–24.352)
|
0.636
|
|
Nuclear grade
|
1.987 (0.753–5.240)
|
0.165
|
1.024 (0.283–3.708)
|
0.971
|
1.076 (0.233–4.956)
|
0.926
|
- aMultivariate analysis excluding the pCR-score
- bMultivariate analysis including the pCR-score
