Table 1 Characteristics in the primary and validation datasets
Factors | Primary dataset | P | Validation dataset | P | ||
|---|---|---|---|---|---|---|
pCR (n  =  81) | Non-pCR (n  =  352) | pCR (n  =  21) | Non-pCR (n  =  86) | |||
Age at diagnosis (%) | ||||||
 < 50 | 46 (56.8) | 209 (59.4) | 0.708 | 11 (52.4) | 48 (55.8) | 0.811 |
 ≥ 50 | 35 (43.2) | 143 (40.6) | 10 (47.6) | 38 (44.2) | ||
Menopausal status (%) | ||||||
 Premenopausal | 45 (55.6) | 221 (62.8) | 0.255 | 10 (47.6) | 49 (56.9) | 0.472 |
 Postmenopausal | 36 (44.4) | 131 (37.2) | 11 (52.4) | 37 (43.1) | ||
T stage (%) | ||||||
 T1–T2 | 39 (48.1) | 161 (45.7) | 0.712 | 11 (52.4) | 39 (45.3) | 0.630 |
 T3–T4 | 42 (51.9) | 191 (54.3) | 10 (47.6) | 47 (54.7) | ||
N stage (%) | ||||||
 N0 | 8 (9.9) | 32 (9.1) | 1.000 | 0 (0.0) | 5 (5.8) | 1.000 |
 N1–N3 | 73 (90.1) | 320 (90.9) | 21 (100.0) | 81 (94.2) | ||
ER status (%) | ||||||
 Positive | 26 (32.1) | 243 (69.0) | < 0.001 | 4 (19.0) | 66 (76.7) | < 0.001 |
 Negative | 55 (67.9) | 109 (31.0) | 17 (81.0) | 20 (23.3) | ||
PR status (%) | ||||||
 Positive | 27 (33.3) | 231 (65.6) | < 0.001 | 7 (33.3) | 59 (68.6) | 0.005 |
 Negative | 54 (66.7) | 121 (34.4) | 14(66.7) | 27 (31.4) | ||
HER2 status (%) | ||||||
 Positive | 44 (54.3) | 75 (21.3) | < 0.001 | 15 (71.4) | 17 (19.8) | < 0.001 |
 Negative | 37 (45.7) | 277 (78.7) | 6 (28.6) | 69 (80.2) | ||
Subtype (%) | ||||||
 HR + /HER2 − | 16 (19.8) | 223 (63.4) | < 0.001 | 3 (14.3) | 59 (68.6) | < 0.001 |
 HR + /HER2 +  | 20 (24.7) | 40 (11.4) | 5 (23.8) | 11 (12.8) | ||
 HR −/HER2 − | 21 (25.9) | 54 (15.3) | 3 (14.3) | 10 (11.6) | ||
 HR −/HER2 +  | 24 (29.6) | 35 (9.9) | 10 (47.6) | 6 (7.0) | ||
Ki-67 index (%) | ||||||
 ≥ 20% | 76 (93.8) | 296 (84.1) | 0.021 | 20 (95.2) | 70 (81.4) | 0.184 |
 < 20% | 5 (6.2) | 56 (15.9) | 1 (4.8) | 16 (18.6) | ||
Nuclear grade (%) | ||||||
 1 or 2 | 40 (49.4) | 252 (71.6) | 0.001 | 11 (52.4) | 59 (68.6) | 0.202 |
 3 | 41 (51.6) | 100 (28.4) | 10 (47.6) | 27 (31.4) | ||
sTILs (%) | ||||||
 Low | 31 (38.3) | 207 (58.8) | 0.001 | 4 (19.0) | 57 (66.3) | 0.001 |
 Moderate | 44 (54.3) | 136 (38.6) | 14 (66.7) | 26 (30.2) | ||
 High | 6 (7.4) | 9 (2.6) | 3 (14.3) | 3 (3.5) | ||
Necrosis (%) | ||||||
 Yes | 22 (27.2) | 67 (19.0) | 0.126 | 6 (28.6) | 13 (14.9) | 0.200 |
 No | 59 (72.8) | 285 (81.0) | 15 (71.4) | 74 (85.1) | ||