Fig. 5
From: Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice
BI 1029539 reduces human peripheral blood inflammatory cell migration and inflammatory mediator release. A, B mPGES-1 inhibition with BI 1029539 reduced TNFα-induced human monocyte and neutrophil migration. Data are mean ± SEM, n = 4, #p < 0.05 vs the control, *p < 0.05 vs the vehicle group. (C-D) mPGES-1 inhibition with BI 1029539 reduced LPS-induced TNF-α and IL-1β production in human peripheral blood. Data are mean ± SEM, n = 5–6, #p < 0.05 vs Control, *p < 0.05 vs the vehicle group. IL-1β, interleukin 1β; LPS, lipopolysaccharide; mPGES-1, microsomal prostaglandin-E synthase; TNFα, tumor necrosis factor