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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice

Fig. 4

BI 1029539 reduces sepsis-induced lung inflammation and tissue damage. Treatment with BI 1029539 reduced A inflammatory cell count at 24 h after CLP, and B prolonged survival following CLP in mPGES-1 knock-in mice. Treatment with BI 1029539 reduced CLP-induced C histological lung damage, and the lung expression of mPGES-1 (green color) and iNOS (green color). Blue color: DAPI staining of cell nuclei in tissue. All values are the mean ± SEM. N = 6–8. #p < 0.05 vs the sham control group, *p < 0.05 vs the vehicle treated-CLP group. BAL, bronchoalveolar lavage; CLP, cecal ligation and puncture; H&E, hematoxylin and eosin; iNOS, inducible nitric oxide synthase; mPGES-1, microsomal prostaglandin-E synthase

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