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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice

Fig. 3

BI 1029539 reduces LPS-induced airway inflammation. Treatment with BI 1029539 reduced LPS-induced lung inflammatory cell accumulation and PGE2 production in bronchoalveolar lavage (BAL) fluid at 6 h after LPS administration in mPGES-1 knock-in mice. A Neutrophils, B Macrophages, C TNF-α, D IL-1β, E PGE2, and F PGI2. The metabolite of PGI2, 6-keto prostaglandin F1α, was used as a surrogate for PGI2 concentration. All values are mean ± SEM, n = 6–8. #p < 0.05 vs sham, *p < 0.05 vs vehicle-treated LPS group. BAL, bronchoalveolar lavage; IL-1β, interleukin 1β; PGE2, Prostaglandin E2; PGI2, prostacyclin; LPS, lipopolysaccharide; TNFα, tumor necrosis factor α

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