Fig. 2

BI 1029539 reduces LPS-induced lung inflammation and tissue damage. A–D Treatment with BI 1029539 reduced BAL protein content, Lung MPO activity, vascular leakage and water content, compared to vehicle controls at 6 h after LPS administration in mPGES-1 knock-in mice. E BI 1029539 treatment reduced LPS-induced histological lung damage (H&E) and lung expression of mPGES-1 (red color), COX-2 (green color) and ICAM-1 (red color) compared with vehicle controls at 6 h after administration of LPS in mice. Blue color: DAPI staining of cell nuclei in tissue. All values are mean ± SEM, n = 6–8. #p < 0.05 vs sham, * < 0.05 vs vehicle-treated LPS group. COX-2, cyclooxygenase-2; H&E, hematoxylin and eosin; ICAM, intracellular adhesion molecule; LPS, lipopolysaccharide; mPGES-1, microsomal prostaglandin-E synthase; MPO, myeloperoxidase