Table 1 Characteristics of patients included in our study. Patients were grouped according to the reason for interruption of ICIs due to irAE or progressive disease
Interruption of IO | ||
|---|---|---|
G3-G4 irAE 18 | PD 186 | |
Sex | ||
Male | 10 | 98 |
Female | 8 | 38 |
Median age | 66.0 | 60.9 |
Site of disease | ||
Bone | 9 | 44 |
Lung | 18 | 73 |
Lymph nodes | 12 | 69 |
Liver | 6 | 19 |
Gland | 4 | 28 |
Synchronous metastatic disease | 10 | 85 |
Metachronous metastatic disease | 8 | 101 |
IMDC score | ||
Good | 1 | 74 |
Intermediate | 17 | 99 |
Poor | 0 | 13 |
IO | ||
Single agent | 12 | 178 |
IO–IO combo | 6 | 8 |
AID | ||
Yes | 2 | 3 |
Not | 16 | 183 |
ECOG PS | ||
0 | 12 | 96 |
1 | 5 | 72 |
2 | 1 | 18 |
Line of treatment | ||
1 | 6 | 8 |
2 | 7 | 117 |
3 | 4 | 49 |
Further line | 1 | 12 |