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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: E3 ubiquitin ligase TRIM29 promotes pancreatic cancer growth and progression via stabilizing Yes-associated protein 1

Fig. 4

TRIM29 positively regulated YAP1 protein level. A and B, in response to upregulating or downregulating TRIM29 expression in pancreatic cancer (PC) cells, the expression level of YAP1 protein also changed, but its mRNA level changed insignificantly (ns means not significantly). C GEPIA database analysis showed that the expression of YAP1 was significantly increased in PC (*p < 0.05, T means tumour; N means normal). D and E, Determination of YAP1 protein and mRNA levels in PC tissues and paired non-tumour tissues using western blotting and qRT-PCR. GAPDH was used as an internal control (** p < 0.01, N = Normal, T = Tumour). Representative images (G) and quantification (F) of YAP1 IHC staining in 126 paired PC and non-cancer tissues. A high YAP1 expression was observed in 62.70% (79/126) (** p < 0.01) of samples. H, Kaplan–Meier survival curves revealed that PC patients with high levels of TRIM29 expression exhibited a shorter overall and disease-free survival than those with lower levels. I Scatter plots of TRIM29 and YAP1 expression in PC tissues (*p < 0.05, r = 0.6575)

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