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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: E3 ubiquitin ligase TRIM29 promotes pancreatic cancer growth and progression via stabilizing Yes-associated protein 1

Fig. 3

Knockdown of TRIM29 induced cell cycle progression and promoted cell apoptosis. A and B, after down-regulating TRIM29 expression in pancreatic cancer (PC) cells, the cell cycle was arrested in the G1 phase (*p < 0.05). C western blot results showed that the expression levels of cyclins Cyclin-D1 and PCNA decreased. D apoptosis experiments confirmed that the proportion of phase apoptosis was significantly increased in shTRIM29 cells (*p < 0.05). E The expression of BAX and caspase 3 was increased in shTRIM29 cells, while that of BCL-2 was reduced. F TUNEL staining images for apoptosis in the two tumour xenograft groups. G, IHC for Ki-67 in the two tumour xenograft groups

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