Fig. 3

Characteristics of our immune and stromal scores. a Eigenvalue matrix in training dataset TCGA LUAD (n = 501). b GO enrichment analysis of top 100 weight genes of immune and stromal related clusters. All FDR < 0.05. c The immune score was linked to favorable OS in training dataset (Log-rank test). d The stromal scores were linked to unfavorable OS in the training datasets (Log-rank test). e Correlation Between Novel TME Scores and cell infiltration (Spearman's correlation). f GSEA of differently expressed genes in patients with high-low immune scores (Up 50% vs. Low 50%). g GSEA of differently expressed genes in patients with high-low stromal scores (Up 50% vs. Low 50%). NMF, Non-negative matrix factorization; TME, tumor microenvironment; IF, inflammation; GSEA, gene set enrichment analysis; OS, overall survival; FDR, false discover rate