Fig. 7

Biological interaction network of m6A regulators in pancreatic cancer. A Correlation heat map showing coexpression among m6A regulators in pancreatic cancer. Red represents a positive correlation between two genes, and blue represents a negative correlation. Darker colors indicate a greater correlation. B, C STRING was used to explore protein–protein interaction (PPI) networks between these writers, erasers, and readers in humans. B Significant Reactome pathway analysis shown via bar plots. The abscissa represents observed gene counts, and the ordinate represents the different pathways enriched. C Significant Gene Ontology (GO) term analysis is shown in bar plots. The abscissa represents observed gene counts, and the ordinate represents genes enriched in 3 hierarchical categories, including biological processes, cellular components, and molecular functions. D Cytoscape was used to visualize GO enrichment analysis of these 20 main m6A regulators in humans. m6A writers present in the green circle; m6A erasers present in the pink circle; and m6A readers present in the blue circle