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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus

Fig. 1

Isolation and characterization of EVs. A Outline of the study design. EVs were isolated from plasma obtained from NGT and GDM pregnancies across gestation. B Mean and mode of the vesicles isolated from NGT and GDM patients in the discovery and validation cohort. C Graphical representation of the vesicle size distribution using a NanoSight NS500 instrument, all gestational age combined in NGT and GDM, and representative image of electron micrograph of exosomes. D Representative Western blot for enriched EVs markers, CD63, CD9 and TSG101, and negative control Grp94, for EVs isolated from normal and GDM at different time points during pregnancy. E Representative images of small RNA profile extracted from EVs from NGT (up image), and GDM (down image). In C insert, Scale bar 100 nm. In AC, E, none of the experiments performed were significantly different between NGT vs. GDM

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