Skip to main content

Table 1 Biological roles of most significantly dose-responsive mRNAs

From: Analysis of lncRNA-miRNA-mRNA expression pattern in heart tissue after total body radiation in a mouse model

Gene symbol Gene name Biological process involvement Previous reports related to radiation
Cdkn1a Cyclin-dependent kinase inhibitor 1A DNA damage-induced apoptosis; cell cycle arrest [53, 54]
Gdf15 Growth differentiation factor 15 Heart-derived hormone; pathogenesis of atherosclerosis [55, 56]
Ckap2 Cytoskeleton associated protein 2 Cell cycle arrest; essential for proper chromosome segregation [57, 58]
Alas2 Aminolevulinic acid synthase 2, erthyroid Hemoglobin metabolism pathway; cardiotoxicity [59, 60]
Aplnr Apelin receptor Coordination of monocyte trafficking in hemeostatic and inflammatory states [61, 62]
Cx3cr1 Chemokine (C-X3-C motif) receptor 1 Chemokine binding; cell adhesion [63, 64]
  1. Genes displayed correspond to the top three most significantly dose-responsive up- and down-regulated mRNAs shown in Fig. 1D. A short-list of biological process involvement and previous reports of involvement in the molecular response to radiation are shown