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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Analysis of lncRNA-miRNA-mRNA expression pattern in heart tissue after total body radiation in a mouse model

Fig. 5

Predicted canonical pathway dysregulation in mouse heart samples based on all differentially expressed mRNAs. IPA was used to perform pathway analysis on all differentially expressed mRNAs to predict pathway involvement, independent of the target relationship with differentially expressed miRNAs. A Heatmap displays the top 35 most significantly dysregulated pathways (B-H p-value < 0.01). A positive z-score indicates predicted activation of the pathway based on gene expression and a negative z-score indicates predicted deactivation of the pathway based on gene expression. Pathways are hierarchically clustered by z-score. B Heatmap shows the log2FC of the 78 differentially expressed genes with involvement in the cluster of activated pathways. C Heatmap shows the log2FC of 79 differentially expressed genes with involvement in the cluster of most deactivated pathways

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