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Table 15 Identified scalp stimulation targets for PTSD

From: Potential scalp stimulation targets for mental disorders: evidence from neuroimaging studies

Cluster ID

Cluster size

Peak T

Peak coordinates

Brain regions

10–20 EEG

system locations

Acupoint

locations

Functions

x

y

z

PTSD-1

95

6.20

− 42

28

14

L IFG/TriIFG/MFG

2 cm posterior to Fp1

0.3 cun anterior and inferior to GB 4

Sustaining attention and managing working memory, regulate self-control

PTSD-2

57

6.20

− 44

40

− 6

L MFG/OrbIFG

2 cm anterior and inferior to F7

1 cun anterior and inferior to GB 5

Language processing and comprehension, emotional recognition (fear, disgust, and anger)

PTSD-3

169

8.26

− 46

20

− 4

L IFG/OrbIFG/TriIFG

1 cm posterior and inferior to F7

0.3 cun anterior and inferior to GB 6

Language processing and comprehension, emotional recognition (fear, disgust, and anger)

PTSD-4

184

8.26

− 40

− 54

44

L IPL/SPL/PCu/AG

P3

GB 18

Sentence generation, reading, calculation, arithmetic learning, abstract coding of numerical magnitude, spatial focusing of attention, performing verbal creative tasks, theory of mind, executive control of behavior, processing a sequence of actions

PTSD-5

345

8.26

− 2

20

42

L SMA/MedFG/SupMFG

Midpoint of Fz and Cz

0.3 cun posterior to GV 22

Motor learning/imagery/control, executive control of behavior, speech motor programming, language processing, working memory, visuospatial and visuomotor attention, inductive reasoning, pain anticipation

PTSD-6

60

7.23

34

10

56

R MFG/SFG

2 cm anterior and lateral to Cz

0.1 cun medial to GB 16

Motor sequencing/planning/learning/imagery, language processing, working memory, episodic long-term memory, visuospatial attention, visuomotor attention, executive control of behavior

PTSD-7

273

8.26

50

22

− 10

R IFG/OrbIFG/TriIFG/OperIFG

1 cm posterior and inferior to F8

0.3 cun anterior and inferior to GB 6

Language processing and comprehension, emotional recognition (fear, disgust, and anger)

PTSD-8

98

7.23

44

− 42

48

R IPL/SMG/PoCG

2 cm anterior and superior to P4

Midpoint of GB 17 and GB 18

Semantic processing, retrieval of unpleasant experiences, working memory, executive control of behavior, visuomotor transformation/motor planning, somatosensory spatial discrimination, social perception and empathy, emotions vs. Self-reflections in decision-making

  1. L, left; R, right; SFG, superior frontal gyrus; MFG, middle frontal gyrus; IFG, inferior frontal gyrus; OrbIFG, orbital inferior frontal gyrus; TriIFG, triangular inferior frontal gyrus; OperIFG, opercular inferior frontal gyrus; SupMFG, superior medial frontal gyrus; MedFG, medial frontal gyrus; SPL, superior parietal lobule; IPL, inferior parietal lobule; SMG, supramarginal gyrus; AG, angular gyrus; PoCG, postcentral gyrus; PCu, precuneus; SMA, supplementary motor area; cm, centimeter; cun, Chinese inches, 1 cun is about 3.33 cm; GB 4, Hanyan; GB 5, Xuanlu; GB 6, Xuanli; GB 16, Muchuang; GB 17, Zhengying; GB 18, Chengling; GV 22, Xinhui