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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: CYB561D2 up-regulation activates STAT3 to induce immunosuppression and aggression in gliomas

Fig. 4

CYB561D2 up-regulation activates STAT3 in gliomas. A Representative western blot and its quantification showing the protein levels of CYB561D2, pSTAT3 and total STAT3 after transfection with CYB561D2 plasmid at indicated dose (0, 0.5, 1, 2 μg/well in 6-well plate) in U251 and U87 cell lines. B Representative immunofluorescence images and its quantification showing the subcellular distribution of STAT3-GFP after transfection with CYB561D2 plasmid (2 μg/well in 6-well plate) in U251 and U87 cell lines. C Left: representative western blot showing the protein levels of CYB561D2, pSTAT3 and total STAT3 in glioma samples. Right: Scatter plot showing the association of CYB561D2 protein level with pSTAT3/total STAT3 ratio (Spearman r = 0.45, P = 0.0098) in glioma samples (n = 35)

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