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Table 2 Predictive utility of exosomes in lung cancer

From: The role of exosomes in lung cancer metastasis and clinical applications: an updated review

Experimental model/source Exosomal component Predictive effect References
Mouse syngeneic tumor model miR-210-3p, miR-193a-3p, and miR-5100 miR-193a-3p alone can differentiate cancer patients from non-cancerous controls, but the combination of the three gives better diagnostic accuracy [86]
Primary SCLC tissues and NSCLC tissues FLI1 exonic circular RNAs Serum exosomal FECR1 is associated with poor survival and clinical response to chemotherapy [104]
Human NSCLC tissue miR‐18a, miR‐20a, miR‐92a, miR‐210, and miR‐126 Prognostic biomarkers in patients with NSCLC—poor prognosis [109]
NSCLC patients eIF4E Independent prognostic factor for shorter overall survival and progression-free survival [111]
Lung cancer patients’ serum miR-574-5p, 328-3p and miR-423-3p Deferential in lung cancer patients with bone metastasis [78]
NSCLC patients miR-330-3p Biomarker for identifying NSCLC with metastatic potential, especially brain metastasis [80]
Serum of NSCLC patients and lung squamous cell carcinoma of patients miR-15a-5p, miR-320a, miR-25-3p, miR-192-5p, let-7d-5p, let-7e-5p, miR-148a-3p, miR-92a-3p, miR-375 and miR-10b-5p Deferential in lung cancer patients and correlates with cancer stage [99]
NSCLC cells miR-34c-3p Diagnostic and prognostic marker for NSCLC with low levels indicating tumor invasion and migration [116]
Serum of lung cancer patients miR-106b Promising diagnostic biomarker and drug target for patients with lung cancer [100]
Serum of lung cancer patients CD317 and EGFR Diagnostic biomarker of NSCLC [101]
Urine and lung tissue of NSCLC patients LRG1 Diagnostic biomarker of NSCLC [102]
Plasma of lung cancer patients CD151, CD171, and tetraspanin 8 Diagnostic biomarker of lung cancer [103]