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Table 4 Clinical trials based on MSCs-exosomes registered in ClinicalTrials.gov (May 2021)

From: A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine

Condition

Source

Study Phase

Participant Number

Route

Study Location

NCT Number

ARDS

BM

1/2

169

Inhalation

China

NCT04602104

Lung diseases

N.A

1

27

Inhalation

China

NCT04313647

COVID-19

N.A

1/2

30

Inhalation

Russian

NCT04491240

BPD

BM

1

18

Intravenous

USA

NCT03857841

COVID-19

BM

1

24

Inhalation

China

NCT04276987

MODS

UC

N.A

60

Intravenous

China

NCT04356300

Drug-Resistant

AT

1/2

60

Intravenous

China

NCT04544215

Chronic wounds

WJ

1

38

Topical

Indonesia

NCT04134676

Ischemic stroke

N.A

1/2

5

Intravenous

Iran

NCT03384433

Dry eye

UC

1/2

27

Eye Drops

China

NCT04213248

Macular holes

UC

Early 1

44

Eye Drops

China

NCT03437759

AD

AT

1/2

9

Nasal Drops

China

NCT04388982

EB

BM

1/2

10

Topical

NA

NCT04173650

  1. Bone marrow (BM), Adipose tissue (AT), Wharton’s jelly (WJ), Umbilical cord (UC), Coronavirus disease 2019 (COVID-19), Bronchopulmonary dysplasia (BPD), Alzheimer’s diseases (AD), Acute respiratory distress syndrome (ARDS), Epidermolysis bullosa (EB), Multiple organ dysfunction syndromes (MODS), Not available (N.A)