Fig. 5
A Mann Whitney U test using PCC and MOC co-localisation values of TRPM3 with actin on NK cells of ME/CFS patients and HC. B Mann Whitney U test using PCC and MOC co-localisation values of TRPM3 with PIP2 on NK cells of ME/CFS patients and HC. Co-localisation values obtained following IL-2 stimulation (20 IU) (control) and pharmacological treatment using PregS (30 µM) and PregS + Ononetin (3 µM). Bar graphs represent correlation between target antigens using PCC represent degree of overlap between target antigens using MOC. Data presented as mean ± SEM and *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. HC, healthy control; ME/CFS, Myalgic encephalomyelitis/chronic fatigue syndrome; PregS, pregnenolone sulfate; Ono, ononetin