Outcomes | SNPs selection | MR methods | Number of SNPs | OR (95% CI) | SE | MR p-value |
---|---|---|---|---|---|---|
COVID-19 susceptibility | Complete | IVW-fixed | 112 | 0.9369 (0.8656–1.0142) | 0.0404 | 0.1070 |
Complete | IVW-random | 112 | 0.9369 (0.8393–1.0460) | 0.0562 | 0.2460 | |
Complete | MR-Egger | 112 | 0.9404 (0.7923–1.1161) | 0.0874 | 0.4834 | |
Complete | Weighted median | 112 | 0.9738 (0.8560–1.1077) | 0.0658 | 0.6860 | |
Complete | MR.RAPS | 112 | 0.9206 (0.8353–1.0146) | 0.0496 | 0.0952 | |
Steiger filtered | IVW-fixed | 109 | 0.9307 (0.8437–1.0268) | 0.0501 | 0.1519 | |
Steiger filtered | IVW-random | 109 | 0.9307 (0.8113–1.0678) | 0.0701 | 0.3057 | |
Steiger filtered | MR-Egger | 109 | 0.9375 (0.7212–1.2187) | 0.1338 | 0.6305 | |
Steiger filtered | Weighted median | 109 | 0.9539 (0.8032–1.1329) | 0.0877 | 0.5907 | |
Steiger filtered | MR.RAPS | 109 | 0.9149 (0.8099–1.0335) | 0.0622 | 0.1528 | |
Outlier removed | MR-PRESSO | 106 | 0.9049 (0.8111–1.0094) | 0.0558 | 0.0759 | |
Outlier removed | IVW-fixed | 106 | 0.9049 (0.8197–0.9988) | 0.0504 | 0.0473 | |
Outlier removed | IVW-random | 106 | 0.9049 (0.8111–1.0094) | 0.0558 | 0.0730 | |
Outlier removed | MR-Egger | 106 | 0.9319 (0.7571–1.1470) | 0.1060 | 0.5071 | |
Outlier removed | Weighted median | 106 | 0.9535 (0.8052–1.1291) | 0.0862 | 0.5806 | |
Outlier removed | MR.RAPS | 106 | 0.8995 (0.8056–1.0043) | 0.0562 | 0.0595 | |
COVID-19 severity | Complete | IVW-fixed | 112 | 0.9503 (0.7410–1.2187) | 0.1269 | 0.6881 |
Complete | IVW-random | 112 | 0.9503 (0.7204–1.2537) | 0.1413 | 0.7185 | |
Complete | MR-Egger | 112 | 0.9412 (0.5998–1.4768) | 0.2299 | 0.7924 | |
Complete | Weighted median | 112 | 0.8956 (0.5803–1.3822) | 0.2214 | 0.6185 | |
Complete | MR.RAPS | 112 | 0.9302 (0.7122–1.2150) | 0.1363 | 0.5954 | |
Steiger filtered | IVW-fixed | 109 | 1.0298 (0.7699–1.3775) | 0.1484 | 0.8432 | |
Steiger filtered | IVW-random | 109 | 1.0298 (0.7496–1.4148) | 0.1621 | 0.8562 | |
Steiger filtered | MR-Egger | 109 | 1.2444 (0.6799–2.2775) | 0.3084 | 0.4798 | |
Steiger filtered | Weighted median | 109 | 1.0766 (0.6639–1.7460) | 0.2467 | 0.7646 | |
Steiger filtered | MR.RAPS | 109 | 0.9679 (0.7052–1.3284) | 0.1615 | 0.8400 | |
Outlier removed | MR-PRESSO | 109 | 1.0277 (0.7512–1.4060) | 0.1599 | 0.8646 | |
Outlier removed | IVW-fixed | 109 | 1.0298 (0.7699–1.3775) | 0.1484 | 0.8432 | |
Outlier removed | IVW-random | 109 | 1.0298 (0.7496–1.4148) | 0.1621 | 0.8562 | |
Outlier removed | MR-Egger | 109 | 1.2444 (0.6799–2.2775) | 0.3084 | 0.4798 | |
Outlier removed | Weighted median | 109 | 1.0766 (0.6639–1.7460) | 0.2467 | 0.7646 | |
Outlier removed | MR.RAPS | 109 | 0.9679 (0.7052–1.3284) | 0.1615 | 0.8400 | |
COVID-19 hospitalization | Complete | IVW-fixed | 111 | 1.1099 (0.9405–1.3098) | 0.0845 | 0.2173 |
Complete | IVW-random | 111 | 1.1099 (0.9230–1.3345) | 0.0940 | 0.2676 | |
Complete | MR-Egger | 111 | 1.2364 (0.9135–1.6736) | 0.1544 | 0.1722 | |
Complete | Weighted median | 111 | 1.1002 (0.8436–1.4349) | 0.1355 | 0.4808 | |
Complete | MR.RAPS | 111 | 1.1043 (0.9145–1.3336) | 0.0962 | 0.3025 | |
Steiger filtered | IVW-fixed | 109 | 1.0713 (0.8819–1.3013) | 0.0992 | 0.4878 | |
Steiger filtered | IVW-random | 109 | 1.0713 (0.8619–1.3315) | 0.1109 | 0.5349 | |
Steiger filtered | MR-Egger | 109 | 1.2068 (0.7968–1.8279) | 0.2118 | 0.3768 | |
Steiger filtered | Weighted median | 109 | 1.0567 (0.7572–1.4747) | 0.1700 | 0.7456 | |
Steiger filtered | MR.RAPS | 109 | 1.0546 (0.8442–1.3176) | 0.1136 | 0.6394 | |
Outlier removed | MR-PRESSO | 109 | 1.0611 (0.8557–1.3159) | 0.1099 | 0.5901 | |
Outlier removed | IVW-fixed | 109 | 1.0713 (0.8819–1.3013) | 0.0992 | 0.4878 | |
Outlier removed | IVW-random | 109 | 1.0713 (0.8619–1.3315) | 0.1109 | 0.5349 | |
Outlier removed | MR-Egger | 109 | 1.2068 (0.7968–1.8279) | 0.2118 | 0.3768 | |
Outlier removed | Weighted median | 109 | 1.0567 (0.7572–1.4747) | 0.1700 | 0.7456 | |
Outlier removed | MR.RAPS | 109 | 1.0546 (0.8442–1.3176) | 0.1136 | 0.6394 |