Outcomes
|
SNPs selection
|
MR methods
|
Number of SNPs
|
OR (95% CI)
|
SE
|
MR p-value
|
---|
COVID-19 susceptibility
|
Complete
|
IVW-fixed
|
112
|
0.9369 (0.8656–1.0142)
|
0.0404
|
0.1070
|
Complete
|
IVW-random
|
112
|
0.9369 (0.8393–1.0460)
|
0.0562
|
0.2460
|
Complete
|
MR-Egger
|
112
|
0.9404 (0.7923–1.1161)
|
0.0874
|
0.4834
|
Complete
|
Weighted median
|
112
|
0.9738 (0.8560–1.1077)
|
0.0658
|
0.6860
|
Complete
|
MR.RAPS
|
112
|
0.9206 (0.8353–1.0146)
|
0.0496
|
0.0952
|
Steiger filtered
|
IVW-fixed
|
109
|
0.9307 (0.8437–1.0268)
|
0.0501
|
0.1519
|
Steiger filtered
|
IVW-random
|
109
|
0.9307 (0.8113–1.0678)
|
0.0701
|
0.3057
|
Steiger filtered
|
MR-Egger
|
109
|
0.9375 (0.7212–1.2187)
|
0.1338
|
0.6305
|
Steiger filtered
|
Weighted median
|
109
|
0.9539 (0.8032–1.1329)
|
0.0877
|
0.5907
|
Steiger filtered
|
MR.RAPS
|
109
|
0.9149 (0.8099–1.0335)
|
0.0622
|
0.1528
|
Outlier removed
|
MR-PRESSO
|
106
|
0.9049 (0.8111–1.0094)
|
0.0558
|
0.0759
|
Outlier removed
|
IVW-fixed
|
106
|
0.9049 (0.8197–0.9988)
|
0.0504
|
0.0473
|
Outlier removed
|
IVW-random
|
106
|
0.9049 (0.8111–1.0094)
|
0.0558
|
0.0730
|
Outlier removed
|
MR-Egger
|
106
|
0.9319 (0.7571–1.1470)
|
0.1060
|
0.5071
|
Outlier removed
|
Weighted median
|
106
|
0.9535 (0.8052–1.1291)
|
0.0862
|
0.5806
|
Outlier removed
|
MR.RAPS
|
106
|
0.8995 (0.8056–1.0043)
|
0.0562
|
0.0595
|
COVID-19 severity
|
Complete
|
IVW-fixed
|
112
|
0.9503 (0.7410–1.2187)
|
0.1269
|
0.6881
|
Complete
|
IVW-random
|
112
|
0.9503 (0.7204–1.2537)
|
0.1413
|
0.7185
|
Complete
|
MR-Egger
|
112
|
0.9412 (0.5998–1.4768)
|
0.2299
|
0.7924
|
Complete
|
Weighted median
|
112
|
0.8956 (0.5803–1.3822)
|
0.2214
|
0.6185
|
Complete
|
MR.RAPS
|
112
|
0.9302 (0.7122–1.2150)
|
0.1363
|
0.5954
|
Steiger filtered
|
IVW-fixed
|
109
|
1.0298 (0.7699–1.3775)
|
0.1484
|
0.8432
|
Steiger filtered
|
IVW-random
|
109
|
1.0298 (0.7496–1.4148)
|
0.1621
|
0.8562
|
Steiger filtered
|
MR-Egger
|
109
|
1.2444 (0.6799–2.2775)
|
0.3084
|
0.4798
|
Steiger filtered
|
Weighted median
|
109
|
1.0766 (0.6639–1.7460)
|
0.2467
|
0.7646
|
Steiger filtered
|
MR.RAPS
|
109
|
0.9679 (0.7052–1.3284)
|
0.1615
|
0.8400
|
Outlier removed
|
MR-PRESSO
|
109
|
1.0277 (0.7512–1.4060)
|
0.1599
|
0.8646
|
Outlier removed
|
IVW-fixed
|
109
|
1.0298 (0.7699–1.3775)
|
0.1484
|
0.8432
|
Outlier removed
|
IVW-random
|
109
|
1.0298 (0.7496–1.4148)
|
0.1621
|
0.8562
|
Outlier removed
|
MR-Egger
|
109
|
1.2444 (0.6799–2.2775)
|
0.3084
|
0.4798
|
Outlier removed
|
Weighted median
|
109
|
1.0766 (0.6639–1.7460)
|
0.2467
|
0.7646
|
Outlier removed
|
MR.RAPS
|
109
|
0.9679 (0.7052–1.3284)
|
0.1615
|
0.8400
|
COVID-19 hospitalization
|
Complete
|
IVW-fixed
|
111
|
1.1099 (0.9405–1.3098)
|
0.0845
|
0.2173
|
Complete
|
IVW-random
|
111
|
1.1099 (0.9230–1.3345)
|
0.0940
|
0.2676
|
Complete
|
MR-Egger
|
111
|
1.2364 (0.9135–1.6736)
|
0.1544
|
0.1722
|
Complete
|
Weighted median
|
111
|
1.1002 (0.8436–1.4349)
|
0.1355
|
0.4808
|
Complete
|
MR.RAPS
|
111
|
1.1043 (0.9145–1.3336)
|
0.0962
|
0.3025
|
Steiger filtered
|
IVW-fixed
|
109
|
1.0713 (0.8819–1.3013)
|
0.0992
|
0.4878
|
Steiger filtered
|
IVW-random
|
109
|
1.0713 (0.8619–1.3315)
|
0.1109
|
0.5349
|
Steiger filtered
|
MR-Egger
|
109
|
1.2068 (0.7968–1.8279)
|
0.2118
|
0.3768
|
Steiger filtered
|
Weighted median
|
109
|
1.0567 (0.7572–1.4747)
|
0.1700
|
0.7456
|
Steiger filtered
|
MR.RAPS
|
109
|
1.0546 (0.8442–1.3176)
|
0.1136
|
0.6394
|
Outlier removed
|
MR-PRESSO
|
109
|
1.0611 (0.8557–1.3159)
|
0.1099
|
0.5901
|
Outlier removed
|
IVW-fixed
|
109
|
1.0713 (0.8819–1.3013)
|
0.0992
|
0.4878
|
Outlier removed
|
IVW-random
|
109
|
1.0713 (0.8619–1.3315)
|
0.1109
|
0.5349
|
Outlier removed
|
MR-Egger
|
109
|
1.2068 (0.7968–1.8279)
|
0.2118
|
0.3768
|
Outlier removed
|
Weighted median
|
109
|
1.0567 (0.7572–1.4747)
|
0.1700
|
0.7456
|
Outlier removed
|
MR.RAPS
|
109
|
1.0546 (0.8442–1.3176)
|
0.1136
|
0.6394
|
- COVID-19 coronavirus disease 2019, SNP single nucleotide polymorphism, MR Mendelian randomization, OR odds ratio, CI confidence interval, IVW-fixed inverse variance weighted with fixed effects, IVW-random inverse variance weighted with random effects, MR.RAPS MR Robust Adjusted Profile Score, MR-PRESSO MR Pleiotropy RESidual Sum and Outlier, 25(OH)D 25-hydroxyvitamin D