Skip to main content
Fig. 7 | Journal of Translational Medicine

Fig. 7

From: The germline/somatic DNA damage repair gene mutations modulate the therapeutic response in Chinese patients with advanced pancreatic ductal adenocarcinoma

Fig. 7

Distribution of TMB based on DNA damage-related gene-set alteration. A The relationship between TMB and the DDR gene status. B–E Comparison of the TMB levels between patients with the mutation of respective subways of DDR systems, HRR (B), CPF (C), NHEJ (D), and FA (E), and those without corresponding mutations. The y axis is indicating TMB per megabase in log2 scale. F Patients with DDR deficiency harbored higher percentage of PD-L1 overexpression compared to those with DDR wild-type. Abbreviations: DDR, DNA damage repair; FA, Fanconi anemia; HR, homologous recombination; NHEJ, non-homologous end joining; CPF, checkpoint factors; TMB, tumor mutation burden

Back to article page