Fig. 5

The respective relationship between OS and olaparib, platinum-based chemotherapy or PD-L1 blocking therapy in defective DDR patients. A The constitution of mutant DDR genes in patients with any one treatment of olaparib, platinum-based chemotherapy and PD-1/PD-L1 blockade. B In the subgroup of locally advanced or metastatic PDACs, there were significant difference between defective DDR patients with or without olapatib treatment. C Application of platinum-based chemotherapy positively correlated with the prolonged OS in locally advanced or metastatic PDAC patients. D The difference of OS between locally advanced or metastatic patients who treated with PD-L1 blockade and those without