Table 3 Diagnostic accuracy of the combined INF-γ and IL-2 for diagnosis of active tuberculosis cases
Classification | Series combination of INF-γ and IL-2 | Parallel combination of INF-γ and IL-2 | ||
|---|---|---|---|---|
n/N | Estimate (95% CI) | n/N | Estimate (95% CI) | |
Sensitivity for active tuberculosis | ||||
All active tuberculosis | 1736/2536 | 68.5 (66.6–70.3) | 2228/2536 | 87.9 (86.5–89.1) |
Definite tuberculosis | 761/1055 | 72.1 (69.3–74.8) | 942/1055 | 89.3 (87.2–91.1) |
Smear-positive tuberculosis | 413/579 | 71.3 (67.4–74.9) | 513/579 | 88.6 (85.7–91.0) |
Smear-negative tuberculosis | 348/476 | 73.1 (68.8–77.0) | 429/476 | 90.1 (87.0–92.6) |
Clinically diagnosed tuberculosis | 975/1481 | 65.8 (63.3–68.2) | 1286/1481 | 86.8 (85.0–88.5) |
Specificity for active tuberculosis | ||||
Active tuberculosis excluded | 689/718 | 96.0 (94.2–97.2) | 573/718 | 79.8 (76.6–82.6) |
Active tuberculosis and LTBI excluded | 495/495 | 100.0 (99.0–100.0) | 470/495 | 94.9 (92.5–96.6) |
Predictive values for all tuberculosis | ||||
Positive predictive value | 1736/1765 | 98.4 (97.6–98.9) | 2228/2373 | 93.9 (92.8–94.8) |
Negative predictive value | 689/1489 | 46.3 (43.7–48.8) | 573/881 | 65.0 (61.8–68.2) |